A rapid and convergent synthesis of the integrastatin core.

نویسندگان

  • Pamela M Tadross
  • Pradeep Bugga
  • Brian M Stoltz
چکیده

The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(II)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 9 15  شماره 

صفحات  -

تاریخ انتشار 2011